Recent Studies in Hyponatremia by Dr. Tomas Berl
Tomas Berl, MD, is Professor of Medicine in the Division of Renal Diseases and Hypertension at the University of Colorado. He was President of the American Society of Nephrology (ASN) in 2005, and has authored or co-authored more than 215 peer-reviewed scientific articles, editorials, reviews, and book chapters. Disclosure: Tomas Berl, MD, is a paid consultant for Otsuka America Pharmaceutical, Inc.
Relationship between admission serum sodium concentrations and in-hospital mortatlity: analysis from OPTIMIZE-HF registry3 Restrictive cubic spline transformation plot with 95% confidence intervals is shown. Adapted with permission from Gheorghiade M, et al. Eur Heart J. 2007;28(8):980-988.
References: 1. Gheorghiade M, Abraham WT, Albert NM, et al; OPTIMIZE-HF Investigators and Coordinators. Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: an analysis from the OPTIMIZE-HF registry. Eur Heart J. 2007;28(8):980-988. 2. Waikar SS, Mount DB, Curhan GC. Mortality after hospitalization with mild, moderate, and severe hyponatremia. Am J Med. 2009;122(9):857-865.
Normal Brain1 (normal osmolality) Water gain (low osmolality) Loss of sodium, potassium, and chloride (low osmolality)
References: 1. Sterns RH, Silver SM. Brain volume regulation in response to hypo-osmolality and its correction.Am J Med. 2006;119(7A)(suppl 1):S12-S16. 2. Ayus JC, Achinger SG, Arieff A. Brain cell volume regulation in hyponatremia: role of sex, age, vasopressin, and hypoxia. Am J Physiol Renal Physiol. 2008;295(3):F619-F624. 3. Adrogué HJ, Madias NE. Hyponatremia. N Engl J Med. 2000;342(21):1581-1589.
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